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Article Dans Une Revue Polymers Année : 2016

Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs

Résumé

A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments.

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hal-04389707 , version 1 (11-01-2024)

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Karolina Walker, Jean-Francois Stumbe, Rainer Haag. Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs. Polymers, 2016, 8 (5), pp.192. ⟨10.3390/polym8050192⟩. ⟨hal-04389707⟩
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